#metabolism

The KEGG molecular database as an API, powered by the official KEGG REST service. KEGG (the Kyoto Encyclopedia of Genes and Genomes) links genomes, chemistry and disease. Fetch any KEGG entry parsed to JSON — a metabolic compound, KEGG Orthology group (KO), enzyme (EC number), reaction, module, drug, disease, glycan, gene or pathway map; search any KEGG database by name; list a database's entries; cross-link entries between databases (a gene to its pathways, a pathway to its compounds, an enzyme to its reactions); and convert KEGG identifiers to and from outside namespaces (NCBI Gene/Protein, UniProt, ChEBI, PubChem). Ideal for systems-biology and metabolomics pipelines, enzyme and orthology mapping, drug and disease research, gene-to-pathway annotation and bioinformatics id conversion. KEGG ids are letter-prefixed (C compound, K orthology, D drug, H disease, M module, R reaction, G glycan) or organism-coded (hsa human, eco E. coli).

api.oanor.com/kegg-api

The Reactome pathway knowledgebase as an API — the open, peer-reviewed database of biological pathways and reactions, powered by the official Reactome ContentService. Search the curated archive of pathways, reactions and molecules; read any entity by its Reactome stable id (a pathway, reaction, complex or protein: name, type, species, compartments, summary and disease flag); list the events (sub-pathways and reactions) contained in a pathway; list the molecules participating in a pathway or reaction with their reference identifiers; get the top-level pathways for any model organism; map a UniProt protein to the pathways it takes part in; and list the supported species. Covers human and 15+ model organisms across metabolism, signal transduction, cell cycle, immune system, disease and more. Ideal for systems-biology and bioinformatics pipelines, pathway-enrichment and drug-target tools, biomedical research apps, teaching resources and life-science chatbots.

api.oanor.com/reactome-api