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API · /reactome-api

Reactome API

healthy 3,078 Subscribers

The Reactome pathway knowledgebase as an API — the open, peer-reviewed database of biological pathways and reactions, powered by the official Reactome ContentService. Search the curated archive of pathways, reactions and molecules; read any entity by its Reactome stable id (a pathway, reaction, complex or protein: name, type, species, compartments, summary and disease flag); list the events (sub-pathways and reactions) contained in a pathway; list the molecules participating in a pathway or reaction with their reference identifiers; get the top-level pathways for any model organism; map a UniProt protein to the pathways it takes part in; and list the supported species. Covers human and 15+ model organisms across metabolism, signal transduction, cell cycle, immune system, disease and more. Ideal for systems-biology and bioinformatics pipelines, pathway-enrichment and drug-target tools, biomedical research apps, teaching resources and life-science chatbots.

#reactome #pathways #reactions #systems-biology #bioinformatics #metabolism #life-sciences
api.oanor.com/reactome-api
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Machine-readable spec so AI agents can integrate this API.

/api/reactome-api/openapi.json
/api/reactome-api/llms.txt

Discovery: GET /api/index.json lists every API.

API health

healthy
Uptime
100.00%
Server probes · 24h
Avg latency
221 ms
Server probes · 24h
Subscribers
3,078
active
Total calls
24
last 7 days
status Full status page → · 48 probes/24h

Pricing

Pick a tier — billed monthly, cancel anytime.

Free

Free

  • 520 calls / month
  • 2 requests / second
  • Hard cap (429 above quota, no overage)
  • 520 calls/month
  • 2 req/sec
  • Search, pathways & mapping
  • No credit card
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Starter

€7.20 /month

  • 17,500 calls / month
  • 6 requests / second
  • Hard cap (429 above quota, no overage)
  • 17.5k calls/month
  • 6 req/sec
  • Pathway & entity lookup
  • Email support
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Pro

€21.20 /month

  • 86,000 calls / month
  • 15 requests / second
  • Hard cap (429 above quota, no overage)
  • 86k calls/month
  • 15 req/sec
  • Participants & UniProt mapping
  • Priority support
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Mega

€58.50 /month

  • 330,000 calls / month
  • 40 requests / second
  • Hard cap (429 above quota, no overage)
  • 330k calls/month
  • 40 req/sec
  • High-throughput systems biology
  • Dedicated SLA
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Protein Interactions API

Protein-protein interaction networks as an API — powered by STRING, the database of known and predicted protein associations that combines evidence from laboratory experiments, curated pathway databases, gene co-expression, genomic context and automated text mining into a single confidence score, across thousands of organisms. Get a protein's top interaction partners (each with the combined confidence score and the seven evidence-channel subscores), the interaction network among any set of proteins as scored edges, and functional enrichment for a gene set — the over-represented GO terms, KEGG pathways, Pfam domains and more, each with its p-value, FDR and member genes. Pass gene symbols (TP53) or STRING/Ensembl ids, for human (default) or any species by NCBI taxon id. It is a cornerstone of systems biology — ideal for network analysis, functional genomics, pathway and bioinformatics tools. A protein-interaction-network resource — distinct from biological pathways (Reactome), curated protein complexes (Complex Portal) and Gene Ontology annotations (QuickGO). Open data from STRING (CC BY 4.0).

api.oanor.com/stringdb-api

BioModels API

BioModels as an API, powered by EMBL-EBI — the world's largest repository of curated, published mathematical models of biological systems. BioModels collects computational models (mostly in SBML, the Systems Biology Markup Language) of metabolism, cell signalling, gene-regulatory networks, the cell cycle, disease processes and physiology, each linked to the peer-reviewed publication it comes from. /v1/search?query=glycolysis searches the repository and returns each matching model's id (such as BIOMD0000000012), name, format, submitter and submission/modification dates. /v1/model?id=BIOMD0000000012 returns a model's metadata — its name and description, the encoding format, the modelling approach (e.g. ordinary differential equation model), the curation status, the publication behind it (title, journal, year, authors) and the model files. Model ids look like BIOMD0000000012 for curated models or MODEL1234567890 for non-curated submissions; get them from the search endpoint. Ideal for systems-biology and computational-modelling tools, reproducible-research and model-reuse workflows, and teaching. Data from EMBL-EBI BioModels (CC0). This is a systems-biology / computational-model repository — distinct from sequence (UniProt, ENA), structure (PDB, AlphaFold), pathway and variant (ClinVar) databases.

api.oanor.com/biomodels-api

STRING API

The STRING protein–protein interaction database as an API — the curated and predicted network of functional associations between proteins, powered by the official STRING API. Resolve gene or protein names to STRING identifiers with annotations; get a protein's top interaction partners with a combined confidence score and per-channel evidence (experimental, curated databases, co-expression, text-mining, gene fusion, neighbourhood and co-occurrence); build the interaction network among a set of proteins as scored edges; run functional enrichment of a gene set over Gene Ontology, KEGG, Reactome, Pfam, InterPro and more with p-values and false-discovery rates; and score homology between proteins. Covers 12,000+ organisms (default human, NCBI taxon 9606). Ideal for systems-biology and network-biology pipelines, gene-set and pathway analysis, drug-target and disease-gene research, and bioinformatics dashboards.

api.oanor.com/string-api

Genome Assemblies API

Reference genome assemblies as an API — powered by NCBI Assembly, the registry of genome builds for organisms across the tree of life. Search assemblies by organism (or free text) and look up any assembly's metadata: its accession (GCF_… RefSeq or GCA_… GenBank), name (e.g. GRCh38.p14), organism and taxon id, assembly level (complete genome, chromosome, scaffold or contig), contiguity statistics (contig and scaffold N50), sequencing coverage, RefSeq category, UCSC and Ensembl names, the submitting organization, release date and FTP download paths. From the human reference genome to any sequenced microbe, plant or animal, it turns the genome-assembly registry into a clean search-and-fetch API. A genome-assembly registry — distinct from sequence (ENA), genome annotation (Ensembl), variant (ClinVar, dbVar) and gene-expression (GEO) databases. Open data from NCBI Assembly (public domain).

api.oanor.com/genomes-api

Frequently asked questions

Quick answers about pricing, quotas, and integration.

How do I get an API key for Reactome API?
Sign up for free at oanor.com, generate an API key from the developer dashboard, and call Reactome API with the x-oanor-key header. No credit card needed for the free tier.
What's the rate limit for Reactome API?
Free tier allows 1 request per second. Paid plans scale up to 50 requests per second on the Mega tier. Hard limits return HTTP 429 above the quota — no surprise overage charges.
How much does Reactome API cost?
Reactome API has a free tier with 100 calls / month. Paid plans start at €7.20 / month with higher quotas and faster rate limits.
Can I cancel my subscription anytime?
Yes. Plans are billed monthly and you can cancel anytime from your billing dashboard. No long-term contracts and no cancellation fee.
Is Reactome API GDPR-compliant?
All requests to Reactome API go through our EU-based gateway. Your upstream API key never leaves our server and no personal data is shared with the upstream provider beyond the request you send.

Pick an endpoint from the list on the left to see its details and try it.

Code snippets

Sign up to get an API key, then call any path under your slug.

curl https://api.oanor.com/reactome-api/SOME_PATH \
  -H "x-oanor-key: oanor_test_..."
const res = await fetch("https://api.oanor.com/reactome-api/SOME_PATH", {
  headers: { "x-oanor-key": "oanor_test_..." }
});
const data = await res.json();
$ch = curl_init("https://api.oanor.com/reactome-api/SOME_PATH");
curl_setopt($ch, CURLOPT_RETURNTRANSFER, true);
curl_setopt($ch, CURLOPT_HTTPHEADER, ["x-oanor-key: oanor_test_..."]);
$response = curl_exec($ch);
import requests
r = requests.get(
    "https://api.oanor.com/reactome-api/SOME_PATH",
    headers={"x-oanor-key": "oanor_test_..."},
)
print(r.json())

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