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API · /opentargets-api

Open Targets API

healthy 3,941 Subscribers

Drug target–disease associations as an API, powered by the Open Targets Platform. Open Targets integrates human genetics, genomics, transcriptomics, known drugs, animal models and the scientific literature to systematically score how strongly a target (gene/protein) is associated with a disease — the evidence that underpins modern drug discovery. Search across targets, diseases and drugs; read a target for its approved symbol, biotype, function, genomic location and UniProt ids together with the diseases it is most strongly associated with and their overall association scores; read a disease for its description, therapeutic areas and its top associated targets with scores; and read a drug for its modality, maximum clinical stage, trade names, synonyms and mechanisms of action. Ideal for drug-discovery and target-identification pipelines, therapeutic-area research, biomedical data science and pharma intelligence tools. Target ids are Ensembl gene ids, disease ids are EFO/MONDO/Orphanet ids, drug ids are ChEMBL ids. Data is open (CC0).

#open-targets #drug-discovery #target-disease #genetics #therapeutics #bioinformatics #life-sciences
api.oanor.com/opentargets-api
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Machine-readable spec so AI agents can integrate this API.

/api/opentargets-api/openapi.json
/api/opentargets-api/llms.txt

Discovery: GET /api/index.json lists every API.

API health

healthy
Uptime
100.00%
Server probes · 24h
Avg latency
275 ms
Server probes · 24h
Subscribers
3,941
active
Total calls
15
last 7 days
status Full status page → · 30 probes/24h

Pricing

Pick a tier — billed monthly, cancel anytime.

Free

Free

  • 520 calls / month
  • 2 requests / second
  • Hard cap (429 above quota, no overage)
  • 520 calls/month
  • 2 req/sec
  • Search, targets & diseases
  • No credit card
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Starter

€7.45 /month

  • 19,200 calls / month
  • 6 requests / second
  • Hard cap (429 above quota, no overage)
  • 19.2k calls/month
  • 6 req/sec
  • Target & disease lookup
  • Email support
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Pro

€22.30 /month

  • 87,800 calls / month
  • 15 requests / second
  • Hard cap (429 above quota, no overage)
  • 87.8k calls/month
  • 15 req/sec
  • Target identification
  • Priority support
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Mega

€60.80 /month

  • 336,000 calls / month
  • 40 requests / second
  • Hard cap (429 above quota, no overage)
  • 336k calls/month
  • 40 req/sec
  • High-throughput drug discovery
  • Dedicated SLA
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Related APIs

Other APIs with overlapping tags.

ChEMBL API

The ChEMBL database of bioactive molecules as an API — the EBI's manually curated knowledgebase of drug-like compounds and their biological activity, powered by the official ChEMBL data API. Look up a compound by its ChEMBL id for its development phase, chemical structure (SMILES, InChIKey), molecular formula and weight, calculated properties (ALogP, polar surface area, hydrogen-bond donors/acceptors, Rule-of-Five violations, QED drug-likeness) and synonyms; search compounds by name; read a biological target with its organism and UniProt protein components; list a drug's mechanisms of action; list its approved and investigational indications (MeSH and EFO terms with development phase); and pull its measured bioactivities (IC50, Ki, EC50, potency…) with values, units, pChEMBL scores, assays and targets. Ideal for drug-discovery and cheminformatics pipelines, medicinal-chemistry and pharmacology tools, target-identification and SAR research, and life-science apps.

api.oanor.com/chembl-api

Polygenic Scores API

Polygenic (risk) scores as an API — powered by the NHGRI-EBI PGS Catalog, the open database of published polygenic scores: weighted combinations of genetic variants used to estimate a person's genetic predisposition to a trait or disease. Search traits by name to find their ontology ids, list every polygenic score developed for a trait, and read a score's full metadata — the reported and mapped (EFO/MONDO) traits, the number of variants in the score, the development method, genome build, the ancestry distribution of the samples it was built and evaluated on, the publication behind it (title, journal, date, PubMed id), the release date, license and a direct link to the scoring file. From breast cancer and coronary artery disease to type 2 diabetes and BMI, it is ideal for statistical genetics, genomics, risk-prediction research and bioinformatics tools. A polygenic-score / genetic-risk-prediction resource — distinct from single-variant association studies (GWAS Catalog), population allele frequencies (gnomAD) and clinical variant interpretation (ClinVar). Open data from the NHGRI-EBI PGS Catalog (CC BY 4.0).

api.oanor.com/pgs-api

GWAS Catalog API

Human genetic trait associations as an API — powered by the NHGRI-EBI GWAS Catalog, the curated reference of published genome-wide association studies. It answers the core question of statistical genetics: which genetic variants (SNPs) are associated with which traits and diseases, and how strongly. Look up a SNP to get its functional class, genomic location and mapped genes; pull every trait association reported for it — the trait, p-value, effect size (odds ratio or beta), risk allele and frequency, and author-reported genes; and read the study behind the evidence — trait, sample sizes, ancestries, genotyping technology and the publication (PubMed id, authors, journal, date). From type 2 diabetes and Crohn disease to systemic lupus erythematosus and hundreds of thousands of associations, it is ideal for genomics, bioinformatics, statistical-genetics and biomedical research tools. A published genetic-association evidence base — distinct from population allele frequencies (gnomAD), clinical variant interpretation (ClinVar) and genome annotation (Ensembl). Open data from the NHGRI-EBI GWAS Catalog (EMBL-EBI).

api.oanor.com/gwas-api

ClinVar API

ClinVar as an API, powered by the US National Library of Medicine via NCBI E-utilities. ClinVar is the public archive of the relationships between human genetic variants and health, recording the clinical significance (interpretation) of each variant — whether it is Pathogenic, Likely pathogenic, of Uncertain significance, Likely benign or Benign — together with the conditions it is associated with. /v1/search?gene=BRCA1 searches ClinVar by gene symbol, or by free text with q= (e.g. a disease or HGVS expression), returning the total number of matching variants and a list of ClinVar variation ids. /v1/variant?id=4852102 returns a variant's summary: its ClinVar accession (VCV…), title, variant type, the variation and cDNA names, the clinical classification and review status, the associated condition(s), the gene(s) and primary gene, the chromosome and location, the protein change and the molecular consequence, plus a link to the ClinVar record. Get a variation id from /v1/search, then fetch its details. Ideal for clinical-genomics and variant-annotation pipelines, rare-disease and genetic-counselling tools, and research dashboards. Data from NCBI ClinVar (public domain). This is clinical variant interpretation — distinct from population allele-frequency databases (such as gnomAD) and from protein/sequence databases. Please keep request rates modest under NCBI fair-use.

api.oanor.com/clinvar-api

Frequently asked questions

Quick answers about pricing, quotas, and integration.

How do I get an API key for Open Targets API?
Sign up for free at oanor.com, generate an API key from the developer dashboard, and call Open Targets API with the x-oanor-key header. No credit card needed for the free tier.
What's the rate limit for Open Targets API?
Free tier allows 1 request per second. Paid plans scale up to 50 requests per second on the Mega tier. Hard limits return HTTP 429 above the quota — no surprise overage charges.
How much does Open Targets API cost?
Open Targets API has a free tier with 100 calls / month. Paid plans start at €7.45 / month with higher quotas and faster rate limits.
Can I cancel my subscription anytime?
Yes. Plans are billed monthly and you can cancel anytime from your billing dashboard. No long-term contracts and no cancellation fee.
Is Open Targets API GDPR-compliant?
All requests to Open Targets API go through our EU-based gateway. Your upstream API key never leaves our server and no personal data is shared with the upstream provider beyond the request you send.

Pick an endpoint from the list on the left to see its details and try it.

Code snippets

Sign up to get an API key, then call any path under your slug.

curl https://api.oanor.com/opentargets-api/SOME_PATH \
  -H "x-oanor-key: oanor_test_..."
const res = await fetch("https://api.oanor.com/opentargets-api/SOME_PATH", {
  headers: { "x-oanor-key": "oanor_test_..." }
});
const data = await res.json();
$ch = curl_init("https://api.oanor.com/opentargets-api/SOME_PATH");
curl_setopt($ch, CURLOPT_RETURNTRANSFER, true);
curl_setopt($ch, CURLOPT_HTTPHEADER, ["x-oanor-key: oanor_test_..."]);
$response = curl_exec($ch);
import requests
r = requests.get(
    "https://api.oanor.com/opentargets-api/SOME_PATH",
    headers={"x-oanor-key": "oanor_test_..."},
)
print(r.json())

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