#drug-discovery

Drug target–disease associations as an API, powered by the Open Targets Platform. Open Targets integrates human genetics, genomics, transcriptomics, known drugs, animal models and the scientific literature to systematically score how strongly a target (gene/protein) is associated with a disease — the evidence that underpins modern drug discovery. Search across targets, diseases and drugs; read a target for its approved symbol, biotype, function, genomic location and UniProt ids together with the diseases it is most strongly associated with and their overall association scores; read a disease for its description, therapeutic areas and its top associated targets with scores; and read a drug for its modality, maximum clinical stage, trade names, synonyms and mechanisms of action. Ideal for drug-discovery and target-identification pipelines, therapeutic-area research, biomedical data science and pharma intelligence tools. Target ids are Ensembl gene ids, disease ids are EFO/MONDO/Orphanet ids, drug ids are ChEMBL ids. Data is open (CC0).

api.oanor.com/opentargets-api

The ChEMBL database of bioactive molecules as an API — the EBI's manually curated knowledgebase of drug-like compounds and their biological activity, powered by the official ChEMBL data API. Look up a compound by its ChEMBL id for its development phase, chemical structure (SMILES, InChIKey), molecular formula and weight, calculated properties (ALogP, polar surface area, hydrogen-bond donors/acceptors, Rule-of-Five violations, QED drug-likeness) and synonyms; search compounds by name; read a biological target with its organism and UniProt protein components; list a drug's mechanisms of action; list its approved and investigational indications (MeSH and EFO terms with development phase); and pull its measured bioactivities (IC50, Ki, EC50, potency…) with values, units, pChEMBL scores, assays and targets. Ideal for drug-discovery and cheminformatics pipelines, medicinal-chemistry and pharmacology tools, target-identification and SAR research, and life-science apps.

api.oanor.com/chembl-api