A target & its associated diseases

Extraits de code

curl "https://api.oanor.com/opentargets-api/v1/target" \
  -H "x-oanor-key: oanor_test_..."

await fetch("https://api.oanor.com/opentargets-api/v1/target", {
  headers: { "x-oanor-key": "oanor_test_..." }
});

$ch = curl_init("https://api.oanor.com/opentargets-api/v1/target");
curl_setopt($ch, CURLOPT_HTTPHEADER, ["x-oanor-key: oanor_test_..."]);
curl_setopt($ch, CURLOPT_RETURNTRANSFER, true);
$out = curl_exec($ch);

import requests
requests.get(
    "https://api.oanor.com/opentargets-api/v1/target",
    headers={"x-oanor-key": "oanor_test_..."}
)

Exemple de réponse

Une réponse réelle de ce endpoint, capturée lors du dernier contrôle de santé.

{
    "data": {
        "target": {
            "id": "ENSG00000012048",
            "end": 43170245,
            "name": "BRCA1 DNA repair associated",
            "start": 43044292,
            "symbol": "BRCA1",
            "biotype": "protein_coding",
            "function": "E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in b",
            "chromosome": "17",
            "uniprot_ids": [
                "P38398",
                "A0A0U1RRA9",
                "A0A2R8Y6Y9",
                "A0A2R8Y7V5",
                "A0A494C182"
            ],
            "associated_diseases": [
                {
                    "id": "MONDO_0007254",
                    "name": "breast cancer",
                    "score": 0.839
                },
                {
                    "id": "Orphanet_145",
                    "name": "Hereditary breast and ovarian cancer syndrome",
                    "score": 0.828
                },
                {
                    "id": "MONDO_0054748",
                    "name": "Fanconi anemia, complementation group S",
                    "score": 0.821
                },
                {
                    "id": "MONDO_0008170",
                    "name": "ovarian cancer",
                    "score": 0.811
                },
                {
                    "id": "MONDO_0011450",
                    "name": "breast-ovarian cancer, familial, susceptibility to, 1",
                    "score": 0.802
                },
                {
                    "id": "EFO_0003869",
                    "name": "breast neoplasm",
                    "score": 0.799
                },
                {
                    "id": "EFO_0003893",
                    "name": "ovarian neoplasm",
                    "score": 0.79
                },
                {
                    "id": "MONDO_0004992",
                    "name": "cancer",
                    "score": 0.755
                },
                {
                    "id": "EFO_0000305",
                    "name": "breast carcinoma",
                    "score": 0.738
                },
                {
                    "id": "EFO_0009044",
                    "name": "Fanconi anemia complementation group A
…