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API · /interpro-api

InterPro API

healthy 4,610 Subscribers

Protein families, domains and functional sites as an API, powered by the EBI InterPro database. InterPro classifies proteins into families and identifies the domains, repeats and important sites they contain, by combining the predictive signatures of many member databases (Pfam, SMART, PROSITE, CDD, PANTHER, SUPERFAMILY, NCBIfam and more) into a single integrated resource. Look up an InterPro entry — a family, domain, repeat, conserved/binding/active site or post-translational modification — with its description, Gene Ontology terms and the member-database signatures that define it; search entries by name and type; read a protein's metadata; and, most usefully, list the InterPro entries found on a protein together with their start–end positions, so you can see a protein's domain architecture. Ideal for protein annotation and function prediction, comparative genomics, structural-biology and bioinformatics pipelines, and research and teaching tools. Entry ids are IPR followed by six digits; protein ids are UniProt accessions. Data from EMBL-EBI.

#interpro #protein-domains #protein-families #bioinformatics #annotation #pfam #life-sciences
api.oanor.com/interpro-api
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Machine-readable spec so AI agents can integrate this API.

/api/interpro-api/openapi.json
/api/interpro-api/llms.txt

Discovery: GET /api/index.json lists every API.

API health

healthy
Uptime
100.00%
Server probes · 24h
Avg latency
208 ms
Server probes · 24h
Subscribers
4,610
active
Total calls
15
last 7 days
status Full status page → · 30 probes/24h

Pricing

Pick a tier — billed monthly, cancel anytime.

Free

Free

  • 510 calls / month
  • 2 requests / second
  • Hard cap (429 above quota, no overage)
  • 510 calls/month
  • 2 req/sec
  • Entries, proteins & domains
  • No credit card
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Starter

€6.95 /month

  • 18,900 calls / month
  • 6 requests / second
  • Hard cap (429 above quota, no overage)
  • 18.9k calls/month
  • 6 req/sec
  • Entry & protein lookup
  • Email support
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Pro

€21.10 /month

  • 86,500 calls / month
  • 15 requests / second
  • Hard cap (429 above quota, no overage)
  • 86.5k calls/month
  • 15 req/sec
  • Domain architecture
  • Priority support
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Mega

€57.80 /month

  • 332,000 calls / month
  • 40 requests / second
  • Hard cap (429 above quota, no overage)
  • 332k calls/month
  • 40 req/sec
  • High-throughput annotation
  • Dedicated SLA
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Genome Assemblies API

Reference genome assemblies as an API — powered by NCBI Assembly, the registry of genome builds for organisms across the tree of life. Search assemblies by organism (or free text) and look up any assembly's metadata: its accession (GCF_… RefSeq or GCA_… GenBank), name (e.g. GRCh38.p14), organism and taxon id, assembly level (complete genome, chromosome, scaffold or contig), contiguity statistics (contig and scaffold N50), sequencing coverage, RefSeq category, UCSC and Ensembl names, the submitting organization, release date and FTP download paths. From the human reference genome to any sequenced microbe, plant or animal, it turns the genome-assembly registry into a clean search-and-fetch API. A genome-assembly registry — distinct from sequence (ENA), genome annotation (Ensembl), variant (ClinVar, dbVar) and gene-expression (GEO) databases. Open data from NCBI Assembly (public domain).

api.oanor.com/genomes-api

Gene Expression API

Functional-genomics experiments as an API — powered by NCBI GEO (Gene Expression Omnibus), the largest public repository of gene-expression data. GEO archives expression series and curated datasets from microarray and high-throughput-sequencing experiments across every organism. Search experiments by keyword and optionally by organism, and look up any series or dataset to get its metadata: title, summary, assay type (expression profiling by array or by sequencing), organism, number of samples, platform and the publication behind it. From β-cell stress studies to cancer transcriptomics across human and mouse, it turns the GEO archive into a simple search-and-fetch API for transcriptomics, bioinformatics and research-data discovery. A gene-expression / functional-genomics dataset repository — distinct from sequence (ENA), variant (ClinVar, dbVar), structure (PDB) and ontology databases. Open data from NCBI GEO (public domain).

api.oanor.com/geodatasets-api

Structural Variants API

Human genomic structural variation as an API — powered by NCBI dbVar, the archive of structural variants (SVs): copy-number variants (CNVs), large deletions, duplications, insertions, inversions and translocations, typically larger than 50 base pairs. This is the structural counterpart to single-nucleotide variant databases: search structural variants overlapping a gene (or by free text) and get each variant's dbVar accession, the study it came from, its type, the genes it overlaps, its genomic placement on GRCh38 and its clinical significance; then look up any variant for the full record — placements on both GRCh37 and GRCh38 assemblies, variant type, genes, clinical significance, study type, methods and variant counts. From BRCA1 CNVs to Cri-du-chat deletions, it is ideal for genomics, cytogenetics, rare-disease and bioinformatics work. A structural-variation / CNV resource — distinct from clinical single-nucleotide variant interpretation (ClinVar), population allele frequencies (gnomAD) and trait associations (GWAS). Open data from NCBI dbVar (public domain).

api.oanor.com/dbvar-api

Protein Interactions API

Protein-protein interaction networks as an API — powered by STRING, the database of known and predicted protein associations that combines evidence from laboratory experiments, curated pathway databases, gene co-expression, genomic context and automated text mining into a single confidence score, across thousands of organisms. Get a protein's top interaction partners (each with the combined confidence score and the seven evidence-channel subscores), the interaction network among any set of proteins as scored edges, and functional enrichment for a gene set — the over-represented GO terms, KEGG pathways, Pfam domains and more, each with its p-value, FDR and member genes. Pass gene symbols (TP53) or STRING/Ensembl ids, for human (default) or any species by NCBI taxon id. It is a cornerstone of systems biology — ideal for network analysis, functional genomics, pathway and bioinformatics tools. A protein-interaction-network resource — distinct from biological pathways (Reactome), curated protein complexes (Complex Portal) and Gene Ontology annotations (QuickGO). Open data from STRING (CC BY 4.0).

api.oanor.com/stringdb-api

Frequently asked questions

Quick answers about pricing, quotas, and integration.

How do I get an API key for InterPro API?
Sign up for free at oanor.com, generate an API key from the developer dashboard, and call InterPro API with the x-oanor-key header. No credit card needed for the free tier.
What's the rate limit for InterPro API?
Free tier allows 1 request per second. Paid plans scale up to 50 requests per second on the Mega tier. Hard limits return HTTP 429 above the quota — no surprise overage charges.
How much does InterPro API cost?
InterPro API has a free tier with 100 calls / month. Paid plans start at €6.95 / month with higher quotas and faster rate limits.
Can I cancel my subscription anytime?
Yes. Plans are billed monthly and you can cancel anytime from your billing dashboard. No long-term contracts and no cancellation fee.
Is InterPro API GDPR-compliant?
All requests to InterPro API go through our EU-based gateway. Your upstream API key never leaves our server and no personal data is shared with the upstream provider beyond the request you send.

Pick an endpoint from the list on the left to see its details and try it.

Code snippets

Sign up to get an API key, then call any path under your slug.

curl https://api.oanor.com/interpro-api/SOME_PATH \
  -H "x-oanor-key: oanor_test_..."
const res = await fetch("https://api.oanor.com/interpro-api/SOME_PATH", {
  headers: { "x-oanor-key": "oanor_test_..." }
});
const data = await res.json();
$ch = curl_init("https://api.oanor.com/interpro-api/SOME_PATH");
curl_setopt($ch, CURLOPT_RETURNTRANSFER, true);
curl_setopt($ch, CURLOPT_HTTPHEADER, ["x-oanor-key: oanor_test_..."]);
$response = curl_exec($ch);
import requests
r = requests.get(
    "https://api.oanor.com/interpro-api/SOME_PATH",
    headers={"x-oanor-key": "oanor_test_..."},
)
print(r.json())

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