This model describes the deterministic version of the repressilator system.

The authors of this model (see reference) use three transcriptional repressor systems that are not part of any natural biological clock to build an oscillating network that they called the repressilator. The model system was induced in Escherichia coli.

In this system, LacI (variable X is the mRNA, variable PX is the protein) inhibits the tetracycline-resistance transposon tetR (Y, PY describe mRNA and protein). Protein tetR inhibits the gene Cl from phage Lambda (Z, PZ: mRNA, protein),and protein Cl inhibits lacI expression. With the appropriate parameter values this system oscillates.

This model is described in the article:

A synthetic oscillatory network of transcriptional regulators.

…(truncated, see openapi.json for full schema) ``` #### `GET /v1/search` — Search the model repository **Parameters:** - `q` (query, required, string) — Search text, e.g. glycolysis Example: `glycolysis` - `limit` (query, optional, string) — Max results (1-100) **Example:** ```bash curl -H "x-oanor-key: $KEY" \ "https://api.oanor.com/biomodels-api/v1/search?q=glycolysis" ``` **Response:** ```json { "data": { "count": 20, "query": "glycolysis", "total": 108, "models": [ { "id": "BIOMD0000000471", "url": "https://www.biomodels.org/BIOMD0000000471", "name": "Smallbone2013 - Yeast metabolic model with linlog rate law", "format": "SBML", "submitted": "2013-02-14T00:00:00Z", "submitter": "Kieran Smallbone", "last_modified": null }, { "id": "BIOMD0000000472", "url": "https://www.biomodels.org/BIOMD0000000472", "name": "Smallbone2013 - Yeast metabolic model with modular rate law", "format": "SBML", "submitted": "2013-02-14T00:00:00Z", "submitter": "Kieran Smallbone", "last_modified": null }, { "id": "BIOMD0000000473", "url": "https://www.biomodels.org/BIOMD0000000473", "name": "Smallbone2013 - Yeast metabolic model with modular rate law, merged with Pritchard 2002", "format": "SBML", "submitted": "2013-02-14T00:00:00Z", "submitter": "Kieran Smallbone", "last_modified": null }, { "id": "BIOMD0000000469", "url": "https://www.biomodels.org/BIOMD0000000469", "name": "Smallbone2013 - E. …(truncated, see openapi.json for full schema) ``` ### Meta #### `GET /v1/meta` — Usage notes **Example:** ```bash curl -H "x-oanor-key: $KEY" \ "https://api.oanor.com/biomodels-api/v1/meta" ``` **Response:** ```json { "data": { "note": "BioModels is EMBL-EBI's repository of curated, published mathematical models of biological systems — metabolism, cell signalling, gene-regulatory networks, disease and physiology — mostly encoded in SBML. /v1/search?q=glycolysis = search the repository, returning each matching model's id (e.g. BIOMD0000000012), name, format, submitter and dates; /v1/model?id=BIOMD0000000012 = a model's metadata — name, description, format, modelling approach, curation status, the publication it comes from (title, journal, year, authors) and the model files. Model ids look like BIOMD0000000012 (curated) or MODEL1234567890 (non-curated). Data from EMBL-EBI BioModels (CC0). A systems-biology / computational-model repository — distinct from sequence (UniProt, ENA), structure (PDB, AlphaFold) and variant (ClinVar) databases. Ideal for systems-biology, modelling and reproducible-research tools.", "source": "EMBL-EBI BioModels (ebi.ac.uk/biomodels)", "endpoints": [ "/v1/search", "/v1/model", "/v1/meta" ] }, "meta": { "timestamp": "2026-06-01T16:23:22.131Z", "request_id": "d35400b4-f8e8-4034-8bd5-e965d98841d2" }, "status": "ok", "message": "Meta retrieved", "success": true } ``` --- Marketplace page: https://www.oanor.com/api/biomodels-api OpenAPI spec: https://www.oanor.com/api/biomodels-api/openapi.json